Abstract
Targeting Tissue Lipids in Age-related Macular Degeneration
Highlights
Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St
In AMD, lipid accumulation can be observed as sub-retinal drusenoid deposits or as thickening of the Bruch's membrane, an elastin-rich layer that separates the RPE from the choriocapillaris
Advanced AMD occurs in two forms that can co-exist: a) geographic atrophy (GA) associated with loss of RPE cells and b) choroidal neovascularization (CNV) characterized by proliferative, anomalous growth of blood vessels underneath the retina that leads to hemorrhage and fibrosis (Fig. 1)
Summary
Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St. Louis, MO 63110, United States article info. A cardinal clinical feature of the disease is extracellular deposition of lipid-rich deposits underneath the retinal pigmented epithelium (RPE) called drusen, which contain high amounts of esterified and unesterified cholesterol (Curcio et al, 2005).
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