Abstract
Targeting SHP2 phosphatase in Myeloproliferative Neoplasms
Highlights
Myeloproliferative neoplasms (MPNs) are clonal hematologic disorders which result in enhanced production of immature and mature myeloid lineagederived cells
While it is clear that Shp2 gain of function (GOF) mutations contribute to non-classical MPN; wildtype (WT) Shp2 is overexpressed and hyperactive in MPNs including in chronic myeloid leukemia (CML) and more recently in cells bearing an oncogenic form of KIT (KITD816V/KITD814V) associated with systemic mastocytosis (SM)[3]
Targeting Shp2 is likely to be of therapeutic benefit for treating juvenile myelomonocytic leukemia (JMML) and for diseases bearing an oncogenic form of KIT including SM
Summary
Myeloproliferative neoplasms (MPNs) are clonal hematologic disorders which result in enhanced production of immature and mature myeloid lineagederived cells. While it is clear that Shp2 gain of function (GOF) mutations contribute to non-classical MPN; wildtype (WT) Shp2 is overexpressed and hyperactive in MPNs including in chronic myeloid leukemia (CML) and more recently in cells bearing an oncogenic form of KIT (KITD816V/KITD814V) associated with SM[3].
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