Targeting redox biology to reverse mitochondrial dysfunction.

David J Marcinek,Michael P Siegel

doi:10.18632/aging.100590

Abstract

Targeting redox biology to reverse mitochondrial dysfunction.

Highlights

There is general agreement that mitochondria play an important role in the aging process, but the role of mitochondrial oxidative stress remains controversial
This is supported by reports demonstrating that mitochondrial enzyme activities, metabolic fluxes, and morphology are sensitive to the redox environment ex vivo and in cells
Our laboratory is interested in whether redox inhibition of mitochondrial function contributes to age-related energy deficits in vivo in mouse and human skeletal muscle [4, 5]

Summary

Introduction

There is general agreement that mitochondria play an important role in the aging process, but the role of mitochondrial oxidative stress remains controversial. This perspective recognizes the important role of reactive oxygen and nitrogen species in regulating adaptive responses to physiological stress (i.e. redox signaling) [3]. One characteristic of this redox signaling is that it typically involves low levels of relatively short-lived oxidative stress under normal physiological conditions.

Results

Conclusion