Abstract
Targeting nutrient retrieval by Francisella tularensis
Highlights
Our continued progress in understanding microbial pathogenesis has been fueled, to a large extent, by the discovery of various translocation systems that inject a large cadre of eukaryotic-like and novel microbial effectors into the host cell
It has been widely presumed that the host cell cytosol is a rich haven of nutrients for microorganisms to proliferate in Abu Kwaik and Bumann (2013)
Recent studies on F. tularensis supports the idea that the levels of host cell amino acids are not sufficient to support the high demands for carbon and energy to support the robust intracellular proliferation of bacterial pathogens that rely on amino acids as major sources of carbon and energy (Alkhuder et al, 2009; Steele et al, 2013)
Summary
Our continued progress in understanding microbial pathogenesis has been fueled, to a large extent, by the discovery of various translocation systems that inject a large cadre of eukaryotic-like and novel microbial effectors into the host cell. Successful pathogens have evolved highly efficient nutrient retrieval strategies to counteract host nutritional limitation or deprivation of major sources of carbon and energy (Abu Kwaik and Bumann, 2013).
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