Abstract
OPINION article Front. Psychiatry, 14 March 2013Sec.Molecular Psychiatry https://doi.org/10.3389/fpsyt.2013.00013
Highlights
Talking about non-continuous antipsychotic treatment in psychiatric practice in our time is tantamount to heresy
In 1960s and 1970s, there was a lot of talk about targeting intermittent treatment throughout the duration of illness, rather than chronic and final phase of schizophrenia
Widespread use of antipsychotics is historically novel that only a small percentage phase four patients are being seen currently by average psychiatrists, but this number may grow in time
Summary
Talking about non-continuous antipsychotic treatment in psychiatric practice in our time is tantamount to heresy. What is known is that in late stages of schizophrenia, antipsychotics become inefficient frequently, despite chronic continuous treatment. The late or chronic stages of schizophrenia are associated with higher antipsychotic doses and diminished clinical response, suggesting tolerance (Remington et al, 1997; Yamin and Vaddadi, 2010). Is it possible that in chronic “burn out” phase of schizophrenia (Figure 1) in which there is neuronal and synaptic loss, a targeted or intermittent antipsychotic treatment is more beneficial to the patient? Tolerance to antipsychotic drugs? Reviewing the current body of evidence, it appears that though the efficacy of antipsychotics in general is proven, a significant proportion of patients suffer from partial
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
