Abstract
NANOPORATION project sets out to explore specific solutions to overcome the current challenges of targeted drug delivery (TDD) to tumours using magnetic resonance imaging guided focused ultrasound (MRgFUS) to cavitate microbubbles (MBs) for increasing cell permeability and to open ‘drug nano-capsules’ for releasing proven active anticancer drugs directly to the tumour site with reduction of drug dosage needed for the desired therapeutic effect.
Highlights
Background/introduction NANOPORATION project sets out to explore specific solutions to overcome the current challenges of targeted drug delivery (TDD) to tumours using magnetic resonance imaging guided focused ultrasound (MRgFUS) to cavitate microbubbles (MBs) for increasing cell permeability and to open ‘drug nano-capsules’ for releasing proven active anticancer drugs directly to the tumour site with reduction of drug dosage needed for the desired therapeutic effect
The desired gamma-CD based carrier greatly reduced DOX’s toxicity in vitro: up to 95% toxicity reduction in KB human enpidermal carcinoma; up to 92% toxicity reduction in HCT116 colorectal carcinomar
The study demonstrated the possibility of translation of the constructed gamma-CD derivative to potential clinical use as a delivery vehicle of DOX for combined thermal and mechanical mechanism by clinically applicable MRgFUS, -triggered TDD for cancer therapy
Summary
Background/introduction NANOPORATION project sets out to explore specific solutions to overcome the current challenges of targeted drug delivery (TDD) to tumours using magnetic resonance imaging guided focused ultrasound (MRgFUS) to cavitate microbubbles (MBs) for increasing cell permeability and to open ‘drug nano-capsules’ for releasing proven active anticancer drugs directly to the tumour site with reduction of drug dosage needed for the desired therapeutic effect. Targeted drug delivery with modified gammaCyclodextrin nanocarriers and MR-guided focused ultrasound triggering From Current and Future Applications of Focused Ultrasound 2014.
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