Abstract
This review aimed to determine the potential of the combination of chitosan and alginate as a targeted drug carrier in cancer therapy. This article is based on the results of previous research journals collected from Google Scholar, Scopus, PubMed and Science Direct sites using the keywords chitosan, alginate, targeted drug delivery for cancer, nanoparticle chitosan alginate. With the inclusion criteria, only English-language journals, journals published in the last 10 y, related to chitosan and alginate-based formulations. Meanwhile, the exclusion criteria were journals on pharmacological properties and bioactivity, food and cosmetics. The combination of cationic chitosan and anionic alginate forming strong cross-links showed good mucoadhesive properties, higher resistance to low pH and high-efficiency encapsulation without showing any obvious cytotoxicity. Ch/Alg can overcome the shortcomings of the active substance, such as its rapid release process and the required active ingredient is lower than that required to enter the cancer target cells so as to minimize side effects of the drug by providing drug-induced release. in response to various stimuli that are well suited to the intended purpose, such as pH stimuli, redox gradients, light, temperature, and magnetism. It is shown that the combination of chitosan and alginate base has great potential in targeting cancer therapy by increasing its therapeutic effectiveness and selectivity.
Highlights
Cancer cells arise from the transformation of normal cells so that anticancer drugs can usually damage normal cells so that a drug delivery system that is targeted towards cancer cells is needed such as nanoparticles [1, 2]
One type of polymer being developed at this time is chitosan; chitosan is a polymer derived from the distillation process of chitin which is widely found in invertebrates, especially crustaceans, such as crabs, crabs, and shrimp, has mucoadhesive properties, biodegradable, biocompatible, low immunogenicity and Non-toxic makes this polymer widely used in biomedicine and pharmaceuticals, besides that it is a strong nucleophile and has a lone pair of electrons from the amine group making chitosan cationic
This article is based on the results of previous research journals collected from the Google Scholar, Scopus, PubMed and ScienceDirect sites using the keywords chitosan, alginate, targeted drug delivery for cancer, nanoparticle chitosan alginate
Summary
Cancer cells arise from the transformation of normal cells so that anticancer drugs can usually damage normal cells so that a drug delivery system that is targeted towards cancer cells is needed such as nanoparticles [1, 2]. In the development of this delivery system, there are three main aspects, namely the targeting group, the therapeutic agent, and the carrier system. Biodegradable polymers have proven to be the most promising potential for building anticancer drug delivery systems and can be classified based on the source consisting of synthetic polymers and natural polymers [1, 2, 6]. One type of polymer being developed at this time is chitosan; chitosan is a polymer derived from the distillation process of chitin which is widely found in invertebrates, especially crustaceans, such as crabs, crabs, and shrimp, has mucoadhesive properties, biodegradable, biocompatible, low immunogenicity and Non-toxic makes this polymer widely used in biomedicine and pharmaceuticals, besides that it is a strong nucleophile and has a lone pair of electrons from the amine group making chitosan cationic. Combination anionic chitosan and alginate will form cross-links that maximize targeting by regulating encapsulation and release rate as well as excellent and proven mucoadhesive properties. can be well received by the body, improve encapsulation efficiency [11,12,13] and is known to increase absorption and cellular uptake by widening the narrow film on the preparation [10, 14, 15]
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