Abstract
The MR/FI bimodal imaging has attracted widely studied due to combining the advantages of MRI and FI can bridge gaps in sensitivity and depth between these two modalities. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by coating the Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The structure of the as-prepared nanocomposite probe is carefully validated via SEM, TEM, and XPS. The content of Mn2+ is calculated through the EDS and TGA. The quantum yield (QY) and emission wavelength of the probe are about 7.24% and 490 nm, respectively. The longitudinal r1 value (2.43 mM−1 s−1) with low r2/r1 (4.45) of the probe is obtained. Subsequently, fluorescence and MR imaging are performed. The metabolic pathways in vivo are inferred by studying the bio-distribution of the probe in major organs. Thus, these results indicate that probe would be an excellent dual-modal imaging probe for enhanced MR imaging and fluorescence imaging.MR/FI bimodal imaging probe is built via in-situ coated Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The in vitro and vivo image property of the probe is evaluated.
Highlights
The poor sensitivity restricts the application of magnetic resonance imaging (MRI) for detecting small tumor nodules [1,2,3]
The fluorescence emission spectra of blue fluorescent emissive carbon quantum dots (BCQD) at different excitation wavelengths and concentrations are exhibited in Fig. S1b, c
The intensity decreases after the introduction of Tannic acid (TA)-Mn coating on the surface of BCQD
Summary
The poor sensitivity restricts the application of magnetic resonance imaging (MRI) for detecting small tumor nodules [1,2,3]. Fluorescent materials commonly used in MRI-FI dual-mode imaging probes include carbon quantum dots (CDs), organic dyes, and metal compounds. Due to the ease of surface functionalization, favorable optical properties, good biocompatibility, excellent water solubility, and low toxicity along with green synthesis, CDs are becoming a superior framework to construct MRI-FI bimodal imaging probes [11,12,13,14,15,16,17,18]. A small number of metal ions bind to the surface of the CDs in Mn-dopped CDs composite, giving rise to MRI properties. The TAmetal network could be reform on various substrates to form a conformal coating [30] This simple and convenient particle surface functionalization technology provides good inspiration for building an MRI-fluorescent dual-mode imaging probe based on manganese ions
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