Tandem reactions of 6-phenylethynylpyrimidine-5-carbaldehydes with alcohols: regioselective synthesis of 5-alkoxy-(7 Z)-7-benzylidene-5,7-dihydrofuro[3,4- d]pyrimidines and 5-alkoxy-7-phenyl-5 H-pyrano[4,3- d]pyrimidines

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An efficient and versatile tandem processes of acetalisation and cycloisomerization reactions have been developed for the reactions of 6-phenylethynylpyrimidine-5-carbaldehydes. The influence of the catalyst and role of the substituent in the position 4 of the pyrimidine ring have been studied. Regioselective synthesis of 5,7-dihydrofuro[3,4- d]pyrimidine and pyrano[4,3- d]pyrimidine cores is described.