Tamquam alter idem: formal similarities in a subset of reports on anti-inflammatory compounds in the years 2008–2019

Abstract

A literature search on the in vitro testing of anti-inflammatory compounds of natural origin revealed a considerable number of studies adopting a similar template for data reporting in the years up to 2019. Sixty-five such reports appear to have been published between the years 2008 and 2019. Interestingly, this format template was clearly recognizable by a few hallmarks, such as a precise way of plotting cell viability data, extremely consistent endpoints, and the way these were graphically represented. In some instances the similarities extended to some textual features, such as in the case of figure legends. The similarity was so high that chance can be excluded and these studies can be safely assumed to have intentionally followed a template. By 2020, however, no new reports following this format have been published. Although a consistent and reproducible formatting for data reporting may improve report readability, this phenomenon should also be closely scrutinized to assess the rationale why it occurred, the validity of the endpoints that were chosen and why it was then abandoned. The present report reviewed the mean features of this format, traced its origin and its evolution over time, while discussing the limitations of this model.