Abstract
This study aimed to investigate the effect of a established cancer drug such as tamoxifen (TMX) when encapsulated into a matrix of copolymer of ethyl acrylate, methyl methacrylate and a low content of methacrylic acid ester with quaternary ammonium groups (EUDRAGIT® RL 100 and RS 100) associated with a fluorescence probe. TMX is used in breast cancer therapy with some side effects such as stroke, and endometrial cancer. This drug delivery system (TMX‐NP) was designed to protect the drug from environmental and to promote a sustained release of the drug and also be tracked by the emission of fluorescence probe. The size and entrapment efficiency were evaluated at different preparation protocols. TMX showed a maximum entrapment efficient of 23% in the proportion of 1.5g of polymer using a emulsion method. The size measurements were compared with the empty nanoparticles and showed values of TMX‐NP = 166.4± 32 nm, and empty NP = 273± 50 nm. The zeta potential of particles was +65 and +38 mV for TMX‐NP and empty NP respectively. The cytotoxicity against the MCF‐7 and 4T1 cells was affected significantly by the released amount of TMX, while empty‐NP exhibit no significant cytotoxicity against breast cancer cells. Supported by FAPDF, CAPES, CNPq, FINATEC and DPP‐UnB.
Published Version
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