Takotsubo cardiomyopathy: a hidden enemy of the hypovolemic patient?

Abstract

Takotsubo cardiomyopathy (TCM) is an underrecognized transient left ventricular dysfunction that mimics clinically an acute coronary syndrome. It has been linked to emotional stress and several clinical entities that provoke a catecholamine surge in the blood stream. We investigated the case of a young female patient who was admitted to the intensive care unit after a significant blood loss due to miscarriage. The patient was fully monitored and was treated for the hypovolemia. A dramatic aggravation of her clinical status was directly linked to the appearance of TCM 1 hour after her admission. This study sought to assess the appearance of TCM in a hypovolemic patient. We found no reports in the literature linking these 2 clinical entities. The blood loss and the pathophysiology of hypovolemia, especially through the excess of catecholamines that are released in the blood stream, seem to provoke the appearance of a subclinical form of TCM. As a result, TCM worsened further the general condition of the patient. There is a high possibility that TCM and hypovolemia can be closely related, and therefore, the treatment of hypovolemia can be adjusted to new standards. Because it has already been proved that TCM can be induced by emotional stress and various pathological entities, further investigations are necessary.