Take care when using lithium with other drugs, as clinically relevant interactions may occur

Abstract

Relatively minor changes in plasma concentrations of lithium can have significant clinical ramifications. Although controlled studies of drug interactions with lithium are limited, accumulated evidence implicates drugs from several classes in the development of lithium toxicity. Consequently, clinicians treating patients with mood disorders need to take a cautious approach when combining lithium with any other medication. This is particularly pertinent in the treatment of elderly patients and those with medical comorbidities.