Tahu yang Difermentasi Rhizopus sp. Menurunkan Kadar Glukosa Darah Tikus Putih(Rattus norvegicus)

Abstract

<p><strong><em>Introductions : </em></strong><em>Control</em><em>l</em><em>ing of blood glucose would be important </em><em>to prevent </em><em>many complications</em><em> of </em><em>DM.</em><em> Consuming fiber is one</em><em> way to maintain blood glucose </em><em>level</em><em>. These amount of fiber could be obtained in tofu fermented by <span style="text-decoration: underline;">Rhizopus sp</span>. This research aimed to know the effect of tofu fermented by <span style="text-decoration: underline;">Rhizopus sp.</span></em><em> in controlling </em><em> blood glucose level of diabetic induced white rats (<span style="text-decoration: underline;">Rattus norvegicus</span>).</em></p><p><strong><em>Methods : </em></strong><em>This research was a laboratoric-experimental study. The subjects were <span style="text-decoration: underline;">Rattus norvegicus</span>grouped randomly. The total 30 <span style="text-decoration: underline;">Rattus norvegicus</span> were injected by Alloxan 15mg/100gramBW, then</em><em> randomly allocated</em><em> into 5 group, positive control group (glibenclamide 0</em><em>.</em><em>05mg/100gramBW/day), negative control group (aquadest), and treatment groups with different doses of fermented tofu (</em><em>0.025gram/100 gramB</em><em>W</em><em>/</em><em>day; </em><em>0.050gram/100 gramBW/</em><em>day; </em><em>0.100gram/100gramBW/</em><em>day). The</em><em> research</em><em> design was </em><em>Pretest and Posttest Control Group Design</em><em>. The</em><em> fasting blood glucose were measured</em><em>before Alloxan injection (day-2), after Alloxan injection (day-5), and after the treatments (day-19).</em></p><p><strong><em>Result</em></strong><strong><em>s</em></strong><strong><em> : </em></strong><em>there was</em><em> a </em><em>significant decreas</em><em>e</em><em> of blood glucose level in all treatment groups and positive control (p = 0</em><em>.</em><em>001). Post Hoc Test showed </em><em>a</em><em> significant difference between all treatment groups and positive control group compared to negative control group (p = 0</em><em>.</em><em>001).</em></p><p><strong><em>Conclusion :</em></strong><em>Tofu fermented by <span style="text-decoration: underline;">Rhizopus sp</span>. was able to decrease blood glucose level in diabetic rats (<span style="text-decoration: underline;">Rattus norvegicus</span>).</em></p><p><em> </em></p><p><strong><em>Keyword </em></strong><em>: Tofu fermented</em><em>, </em><em><span style="text-decoration: underline;">Rhizopus sp</span></em><em><span style="text-decoration: underline;">.</span></em><em>, blood glucose level, alloxan, glibenclamide</em><strong></strong></p>