Abstract
ABSTRACT We report a case of a 44-year-old woman with a history of orthotopic heart transplant on tacrolimus (TC) for immunosuppression who developed large-volume hematochezia. She was found to have a large mid-esophageal ulcer and several large colon ulcers. Biopsies showed granulation tissue and inflammatory debris without an identifiable culprit. Extensive workup was performed, including for infectious causes, which was unrevealing. TC was ultimately considered to be a possible culprit, and after stopping it, all her symptoms improved. We suggest considering TC as the possible cause of gastrointestinal ulcers if no other culprit can be identified.
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