Tacrolimus use in renal and cardiac pediatric transplantation: no increased risk of food allergies

Abstract

Food allergies have been shown to occur in increased prevalence in children after orthotopic liver transplantation from nonatopic donors. 1 Lebel M.J. Chapdelaine H. Paradis L. Des Roches A. Alvarez F. Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. Pediatr Transplant. 2014; 18: 733-739 Crossref PubMed Scopus (19) Google Scholar , 2 Nowak-Wegrzyn A.H. Sicherer S.H. Conover-Walker M.K. Wood R.A. Food allergy after pediatric organ transplantation with tacrolimus immunosuppression. J Allergy Clin Immunol. 2001; 108: 146-147 Abstract Full Text PDF PubMed Scopus (54) Google Scholar , 3 Levy Y. Davidovits M. Cleper R. Shapiro R. New-onset post-transplantation food allergy in children—is it attributable only to the immunosuppressive protocol?. Pediatr Transplant. 2009; 13: 63-69 Crossref PubMed Scopus (48) Google Scholar , 4 De Bruyne R. Dullaers M. Van Biervliet S. et al. Post-transplant food allergy in children is associated with liver and not with renal transplantation: a monocentric comparative study. Eur J Pediatr. 2013; 172: 1069-1075 Crossref PubMed Scopus (37) Google Scholar , 5 Ozdemir O. Arrey-Mensah A. Sorensen R.U. Development of multiple food allergies in children taking tacrolimus after heart and liver transplantation. Pediatr Transplant. 2006; 10: 380-383 Crossref PubMed Scopus (51) Google Scholar , 6 Brown C. Haringman N. Davies C. et al. High prevalence of food sensitisation in young children with liver disease: a clue to food allergy pathogenesis. Pediatr Allergy Immunol. 2012; 23: 771-778 Crossref PubMed Scopus (25) Google Scholar , 7 Wisniewski J. Lieberman J. Nowak-Wegrzyn A. et al. De novo food sensitization and eosinophilic gastrointestinal disease in children post liver transplantation. Clin Transplant. 2012; 26: E365-E371 Crossref PubMed Scopus (34) Google Scholar , 8 Frischmeyer-Guerrerio P.A. Wisniewski J. Wood R.A. Nowak-Wegrzyn A. Manifestations and long-term outcome of food allergy in children after solid organ transplantation. J Allergy Clin Immunol. 2008; 122: 1031-1033 Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar Immunosuppression with tacrolimus (TAC) and young age at transplantation have been identified as important risk factors for the development of transplant-acquired food allergy (TAFA), although the pathophysiology remains unclear. 1 Lebel M.J. Chapdelaine H. Paradis L. Des Roches A. Alvarez F. Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. Pediatr Transplant. 2014; 18: 733-739 Crossref PubMed Scopus (19) Google Scholar , 2 Nowak-Wegrzyn A.H. Sicherer S.H. Conover-Walker M.K. Wood R.A. Food allergy after pediatric organ transplantation with tacrolimus immunosuppression. J Allergy Clin Immunol. 2001; 108: 146-147 Abstract Full Text PDF PubMed Scopus (54) Google Scholar , 3 Levy Y. Davidovits M. Cleper R. Shapiro R. New-onset post-transplantation food allergy in children—is it attributable only to the immunosuppressive protocol?. Pediatr Transplant. 2009; 13: 63-69 Crossref PubMed Scopus (48) Google Scholar , 4 De Bruyne R. Dullaers M. Van Biervliet S. et al. Post-transplant food allergy in children is associated with liver and not with renal transplantation: a monocentric comparative study. Eur J Pediatr. 2013; 172: 1069-1075 Crossref PubMed Scopus (37) Google Scholar , 5 Ozdemir O. Arrey-Mensah A. Sorensen R.U. Development of multiple food allergies in children taking tacrolimus after heart and liver transplantation. Pediatr Transplant. 2006; 10: 380-383 Crossref PubMed Scopus (51) Google Scholar , 6 Brown C. Haringman N. Davies C. et al. High prevalence of food sensitisation in young children with liver disease: a clue to food allergy pathogenesis. Pediatr Allergy Immunol. 2012; 23: 771-778 Crossref PubMed Scopus (25) Google Scholar , 7 Wisniewski J. Lieberman J. Nowak-Wegrzyn A. et al. De novo food sensitization and eosinophilic gastrointestinal disease in children post liver transplantation. Clin Transplant. 2012; 26: E365-E371 Crossref PubMed Scopus (34) Google Scholar , 8 Frischmeyer-Guerrerio P.A. Wisniewski J. Wood R.A. Nowak-Wegrzyn A. Manifestations and long-term outcome of food allergy in children after solid organ transplantation. J Allergy Clin Immunol. 2008; 122: 1031-1033 Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar The objective of this study was to establish whether TAFA was observed after renal and cardiac transplantations and to determine whether the type of solid organ transplanted and/or immunosuppression protocol played a role in the development of TAFA.