Abstract
The aim of this study was to determine whether tachykinin receptors might be involved in the mediation of the atropine- and capsaicin-sensitive third phase of a triphasic contractile response to vagal nerve stimulation of the guinea-pig isolated oesophagus. The third phase was inhibited 23.3 ± 1.7% (P< 0.001, n = 5) and 30.8 ± 9.0% (P< 0.05, n = 5) by the NK3receptor antagonist, SR 142 801 (0.1 and 1 μM respectively). SR 142 801 (0.1 and 1 μM) had no significant effect on the response to a submaximal concentration of acetylcholine (0.1 mM, n = 4). The third phase was not significantly affected by NK1or NK2receptor antagonists. Thus, in the guinea-pig oesophagus, it appears that while NK1and NK2receptors are not involved, NK3receptors play a minor role in mediating a contractile response when afferent neurones are excited by vagal nerve stimulation.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call