Abstract
Cancer stem cells are a key population participating in the promotion of the cervical cancer progression through interacting with cancer cells. Existing studies have preliminary revealed that cervical cancer stem cells contribute to tumor recurrence and chemotherapy resistance. However, the specific mechanisms involved in regulating cell functions remain largely unknown. Here, we analyzed published data from public databases and our global transcriptome data, thus identifying cancer-related signaling pathways and molecules. According to our findings, upregulated TAB2 was correlated to stem cell-like properties of cervical cancer. Immunohistochemistry staining of TAB2 in normal and cervical cancer tissues was performed. The cell function experiments demonstrated that knockdown of TAB2 reduced the stemness of cervical cancer cells and, importantly, prevented cervical cancer progression. Collectively, the therapeutic scheme targeting TAB2 may provide an option for overcoming tumor relapse and chemoresistance of cervical cancer via obstructing stemness maintenance.
Highlights
Cervical cancer (CC) is one of the leading causes for cancer mortality in females in developing countries, with an annual incidence of 560,000 new cases and 300,000 deaths worldwide in 2018 [1]
Consistent results were found in the subsequent Western blotting assay as higher protein levels of BMI1 and SOX2 were detected in Siha sphere than in Siha cells (Figure 1(c))
We found that TAB2 was significantly positively correlated with the mRNA levels of BMI1 and SOX2, which are cancer stem cells (CSCs)-related molecules
Summary
Cervical cancer (CC) is one of the leading causes for cancer mortality in females in developing countries, with an annual incidence of 560,000 new cases and 300,000 deaths worldwide in 2018 [1]. Recent advances have highlighted the existence of a group of cells in tumors that are highly plastic and selfrenewing, which are known as cancer stem cells (CSCs). CSCs are featured by the ability to differentiate into tumor cell populations in response to stimuli from the surrounding microenvironment [5]. They share the same characteristics as normal stem cells, such as self-renewal, migration, differentiation, and avoidance of apoptosis. Emerging studies have confirmed the vital role of CSCs in oncogenesis and progression, which are capable of determining tumor progression rate, metastasis, tumor chemotherapy resistance, and disease prognosis.
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