Abstract
Stimulation of N-methyl-D-aspartic acid receptors (NMDARs) and the resulting activation of neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) production are crucial for fear memory formation. NMDAR antagonists and NOS inhibitors disrupt fear conditioning but have non-specific effects. In this study, we explore the hypothesis that nNOS and PSD95 interaction is critical for fear memory formation and disrupting this protein-protein interaction will reduce conditioned fear with a better side-effects profile.
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