Abstract
Persons exhibiting clinical high-risk (CHR) symptoms similar to but less severe than those of schizophrenia have an elevated risk of developing this disorder. We previously found that CHR patients have reductions in the N400 event-related brain potential (ERP) semantic priming effect, indicating deficits in using meaningful stimuli to activate related concepts in semantic memory. We sought evidence that this abnormality is associated with real-world functional impairment in CHR patients, hypothesizing that N400 semantic priming deficits would correlate with lower social and role functioning in this group.
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