T1502: Performance Characteristics of K-RAS and LOH Mutation Patterns in Predicting Mucinous Pancreatic Cyst Histology

Abstract

Commercially available pancreatic cyst fluid DNA analysis (RedPath) maybe helpful in the evaluation of pancreatic cysts (PCs). Early studies have demonstrated that a k-ras mutation has a high predictive value for mucinous histology and that multiple high amplitude loss of heterozygosity (LOH) mutations may be predictive of malignancy. However, few data exist regarding the prevalence of specific LOH mutations and the predictive value of specific LOH mutations for mucinous histology.