Abstract
Background. Long-term high-dose prednisolone is standard treatment for subacute inflammatory myopathies. Pulsed dexamethasone may have fewer side effects than daily prednisolone. We compared effectiveness and safety of prednisolone and pulsed dexamethasone in newly diagnosed adult patients with dermatomyositis or non-specific myositis. Methods. Patients were assigned to 28-day cycles of oral high-dose dexamethasone or daily high-dose prednisolone in a long-term, prospective, multicentre, double-blind randomised controlled clinical trial.
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