Abstract
Syngeneic graft-versus-host disease (SGVHD), characterized by a TH1 cytokine response, and intestinal inflammation develops following lethal irradiation, reconstitution with syngeneic bone marrow, and treatment for 21 days with cyclosporine A (CsA). It has generally been assumed that the T cell responses associated with SGVHD resulted from the reconstitution of irradiated recipients with donor bone marrow. However, to determine the origin of the effector cells that mediate SGVHD, syngeneic bone marrow from normal immunocompetent mice or immunodeficient mice were transferred into lethally irradiated recipients.
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