T-cell immunoglobulin and mucin-domain-containing molecule-1 in peripheral blood mononuclear cells in Henoch-Schönlein purpura

Abstract

The T cell immunoglobulin- and mucin domain-containing molecules (Tim) have been implicated in the pathogenesis of immune diseases. In this study, we used quantitative real time reverse transcription polymerase chain reaction to examine the Tim 1 mRNA expression in peripheral blood mononuclear cells from Henoch Schonlein purpura patients. The results showed that Tim1 mRNA expression was significantly higher in patients, which was closely correlated with serum TNFa, IL4 levels, IgA1 levels.