Abstract
Hypereosinophic syndrome (HES) is a heterogenous group of disorders comprising various etiology. Idiopathic HES is diagnosis of exclusion after morphological, radiological and molecular investigations. Cytogenetic analysis remains an important diagnostic test available in HES. The patient reported here presented with hyper eosinophilia with cardiac, gastrointestinal and pulmonary organ involvement. Chromosomal abnormality of t (1;12) (p31; q13) was found in conventional karyotyping (unstimulated culture, GTG banding) on bone marrow sample. Patient improved after short course of corticosteroid and imatinib mesylate a tyrosine kinase inhibitor (TKI).
Published Version
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