Abstract
Many human diseases, including obesity, diabetes and atherosclerosis, are accompanied by chronic inflammation and closely connected to oxidative stress (OS). OS can oxidize virtually all biomolecules of which lipids represent one of the most prominent targets. Lipid peroxidation products (LPPs) are chemically diverse group of biomolecules with a variety of functional activities. Many LPPs were shown to play an important role in the onset and development of OS-related diseases and can serve as diagnostic and prognostic biomarkers. However, to include LPPs in a systems medicine view on obesity, the information on their structures, activities and functions as well as associations with various pathological conditions need to be collected and summarized. Based on a comprehensive meta-study including over 170 publications focusing on the enzymatic and non-enzymatic LPPs production, networks of enzymatic and free-radical-driven oxidative reactions were reconstructed for the ten most abundant PUFAs (18:2, 18:3 n-3, 18:3 n-6, 20:3 n-6, 20:4 n-6, 20:5 n-3, 22:4 n-6, 22:5 n-3, 22:5 n-6, and 22:6 n-3). Reconstructed networks allowed to illustrate differences and similarities in PUFAs oxidation mechanisms and were further used to design in silico oxidation algorithms. PUFAs based LPP networks will be further enriched with available information on LPPs involvement in different cellular pathways and integrated into more complex metabolic networks of phospholipids oxidation.
Published Version
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