Abstract
Rosacea is a polietiologic disease with a complex pathogenesis, resulting in the problem is the selection of therapeutic tactics, especially in severe disease. The result of the study revealed that the isotretinoin treatment for rosacea had a positive result, even in the absence of the effect of previous systemic antibiotic therapy. Aim of the study. To study the effect and tolerability of systemic isotretinoin treatment for severe rosacea that is resistant to antibiotic therapy. Materials and methods. Under the supervision and treatment were 16 patients with severe course of rosacea, 14 of them had pustules and papules and 2 - fimatodes subtype. The severity was estimated by the method a 4-point scale proposed by V.P. Adaskevich, and was in average 18.6 points. All patients had a duration of 3 ± 1.2 years for systemic antibacterial therapy (clarithromycin, Ornidazole) with insufficient effect in the past. All patients (n = 16) was conducted therapy with isotretinoin (using Aknekutan). Daily dose was calculated on body weight, the initial dose was 0.2-0.3 mg/ kg, with subsequent dose reduction. Topically patients received clindamycin phosphate gel 1% treatment (5-7 days), then metronidazole 1% cream (Rosamet) 1-2 times a day. The duration of therapy ranged from 3 to 5 months. Results. After the course of therapy using Aknekutan remission or significant improvement was achieved in 87.5% of cases. The severity of the disease fell to 6.5 points, i.e. 2.8 times. Conclusion. Aknekutan showed a high therapeutic effect in severe rosacea, so it can be recommended to patients with resistance to conventional therapy. As external therapy, and supportive treatment patients are recommended - cream metronidazole 1% (Rosamet) and adequate skin care, photoprotective creams.
Highlights
Rosacea is a polietiologic disease with a complex pathogenesis, resulting in the problem is the selection of therapeutic tactics, especially in severe disease
The result of the study revealed that the isotretinoin treatment for rosacea had a positive result, even in the absence of the effect of previous systemic antibiotic therapy
To study the effect and tolerability of systemic isotretinoin treatment for severe rosacea that is resistant to antibiotic therapy
Summary
Розацеа представляет собой полиэтиологическое заболевание со сложным патогенезом, вследствие чего проблемой является выбор терапевтической тактики, особенно при тяжелом течении заболевания. Изучить эффект и переносимость системного изотретиноина при тяжелом течении розацеа, резистентном к антибиотикотерапии. Адаскевичем, и составляла в среднем 18,6 балла. Наружно пациенты получали в начале лечения клиндамицина фосфат гель 1% 5—7 дней, затем метронидазол в виде 1% крема (Розамет) 1—2 раза в день. Степень тяжести заболевания снизилась и составила в среднем 6,5 балла, то есть в 2,8 раза. Препарат Акнекутан показал высокий терапевтический эффект при тяжелом течении розацеа, поэтому его можно рекомендовать пациентам с резистентностью к традиционной терапии. В качестве наружной терапии и поддерживающего лечения пациентам могут быть рекомендованы крем метронидазол 1% (Розамет), а также адекватный уход за кожей, фотопротективные средства. Ключевые слова: розацеа, папуло-пустулезный подтип, тяжелое течение, изотретиноин, Акнекутан
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have