Abstract
AimsTo investigate systemic risk factors contributing to the formation of sialolithiasis.MethodsA retrospective big-data cohort study was conducted using data from Clalit HMO in Israel. Sialolithiasis patients were identified based on ICD-10 codes and matched with controls. Univariate and multivariable logistic regression analyses were performed to assess the relationship between systemic conditions and sialolithiasis. P-value < 0.05 was considered significant.Results5100 sialolithiasis cases were collected. The statistical analysis revealed that hypertension (OR = 1.14, 1.08–1.24, p < 0.001), dyslipidemia (OR = 1.33, 1.27–1.41, p < 0.001), nephrolithiasis (OR = 1.55, 1.42–1.63, p < 0.001) and cholelithiasis (OR = 1.22, 1.16–1.27, p < 0.001) were significantly correlated with sialolithiasis.ConclusionsSystemic diseases, particularly dyslipidemia, play a role in the development of sialolithiasis. Further research is needed to explore the underlying mechanisms linking these conditions and to develop targeted strategies for the prevention of sialolithiasis.Clinical relevanceThis study highlights the potential interplay between systemic conditions and sialolithiasis. Recognizing these associations can inform clinical practice in understanding the pathogenesis of the disease, risk assessment, early diagnosis, and preventive measures.
Published Version
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