Abstract
Aim. To determine and compare the levels of systemic inflammation markers (C-reactive protein (CRP) and cytokines) in different age groups of hypertensive patients with coronary artery disease (CAD).Material and Methods. The study involved 106 patients (men) with hypertension and stable angina. Group 1 included 59 young and middle-aged individuals (52 [46.5; 55] years); group 2 comprised 47 elderly individuals (64 [62; 67] years; p < 0.001). The exclusion criteria were female gender, diabetes, myocardial infarction in the previous six months, exacerbation phase of chronic diseases, acute infectious and mental illnesses. The CRP levels were determined by ELISA test system (Biomerica, USA). The serum cytokine levels were assessed using Vector Best test systems (Russia). Statistical processing of data was performed in the freely distributed Rstudio software. The differences were considered statistically significant if p < 0.05.Results. The levels of CRP and the frequencies of its increase did not significantly differ in patients with hypertension and CAD in different age groups and were within the reference values, which was, probably, due to the use of drugs with systemic antiinflammatory effect. Increases in the IL-6 levels were more common in group of young and middle-aged men (47, 85.5%/27, 62.8%, p = 0.032). Increases in the IL-8 levels were also more frequently detected in young and middle-aged patients (10.7 [7.3; 19]/5.9 [4.35; 9.3], p = 0.006).Conclusion. Obtained data suggest both an increased risk of acute cardiovascular events and more aggressive course of CAD in young and middle-aged patients with hypertension, and a possible onset of early vascular aging in this group.
Highlights
The CRP levels were determined by ELISA test system
The differences were considered statistically significant if p
Increases in the IL-6 levels were more common in group
Summary
В иcследовании участвовали 98 мужчин, больных АГ 1–3 cтепени и стабильной стенокардией напряжения 1–3 функционального класса, в том числе 55 человек молодого и среднего возраста (52 [46,5; 55] лет) – 1-я группа и 43 пожилых (64 [62; 67] лет; р < 0,001) – 2-я группа. У всех больных диагноз АГ был подтвержден анамнезом, результатами физикального осмотра, данными суточного мониторирования АД. Диагноз ИБС был подтвержден результатами коронарографии (КАГ), указывающими на наличие атеросклеротического поражения любой коронарной артерии. СРБ определяли методом иммуноферментного анализа (ИФА) с помощью тест-системы ELISA (Biomerica), США. Для оценки уровня СРБ в крови использовались Российские рекомендации ВНОК 2012 г. Для оценки уровня воспалительных биомаркеров ориентиром были данные клинической проверки уровней, соответствующих ИЛ крови, взятой у здоровых лиц – жителей юго-восточного региона Западной Сибири в возрасте от 20 до 50 лет, и представленные в инструкциях к наборам для ИФА. Для проверки нормальности распределений использовался критерии Шапиро – Уилка. Вследствие отсутствия нормальности распределения у большинства (98%) исследуемых показателей для статистической проверки гипотез о равенстве числовых характеристик выборочных распределений в сравниваемых группах использовался непарный U-критерий Манна – Уитни.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.