Systemic factors associated with adipose tissue remodeling after severe burn injury in children (1160.2)

Abstract

The chronic adrenergic stress response to severe burn injury a causes plethora of metabolic abnormalities. However, the impact of burn injury on adipose tissue (AT) metabolism remains largely unknown. Here, we studied the effect of severe burn injury on systemic biomarkers thought to be involved in AT remodeling (i.e. White‐to‐brown transdifferentiation).Ten severely burned children (age 12±4 years; % total burn surface area 49±20) and ten healthy children (age 12±5 years) participated in this study. Hormones levels were measured by luminex multiplex magnetic assay kit and ELISA kit in plasma samples obtained in the fasted state (2‐4 weeks post injury in burned patients).Plasma fibroblast growth factor 21 (634 vs 40 pg/ml, (p=0.07), leptin (9 vs 1.2 ng/ml; p=0.055), interleukin ‐ 6 (68 vs 4.8 pg/ml; p=0.03) and amylin (65 vs 24 ng/ml, p=0.06) were all increased systemically in burn patients vs. healthy subjects. Irisin also showed a trend to be increased in burn patients (116 vs 83 ng/ml, p=0.24), however this was not statistically different. These findings suggest that severe chronic inflammatory stress alters the systemic hormonal profile of burn patients in a similar manner to that observed during adrenergic stimulation in rodents that has been shown to result in white‐to‐brown transdifferentiation.Grant Funding Source: NIH (P50‐GM60338, R01‐GM05668) and SHC (84090, 84080, 71008 and 71006) g