Abstract
Review question/objective The objective of this review is to assess the effectiveness of trace element supplementation on clinically meaningful outcomes following severe burn injury in children and adults. More specifically, the objectives are to assess the effectiveness of selenium, copper and zinc supplementation on mortality, length of intensive care unit (ICU) hospital stay, wound healing and infection rates (wound and nosocomial) in patients who have sustained a severe burn injury. Inclusion criteria Types of participation This review will consider studies that include children (2-18 years of age) and adults (≥ 18 years of age) who have sustained a severe burn injury (defined as burn injury ≥ 10% Total Body Surface Area (TBSA) in children and ≥ 15% TBSA in adults) and been admitted to an ICU, Burns ICU (BICU), or burns unit for surgical management of their injury. Studies that include patients with significant multi-trauma in addition to burn injury will be excluded. Types of intervention(s)/phenomena of interest This review will consider studies that evaluate enteral or parenteral supplementation of selenium, copper and zinc, either alone or combined and compared to placebo or regular treatment. Intervention and comparison groups will have received standard nutrition intervention including enteral or parenteral nutrition and multi-vitamin supplements. Studies that include trace element supplementation in combination with other predefined nutrient supplementations will be considered for inclusion. Types of outcomes This review will consider studies that include the following outcome measures: mortality; length of ICU/ hospital stay; rate of wound healing (time to first donor site healing or time to wound closure); complications (e.g. wound infection, hospital acquired pneumonia). Secondary outcome measures: tissue (measured from skin biopsies) and plasma (measured via blood sampling) selenium, copper and zinc levels.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JBI Database of Systematic Reviews and Implementation Reports
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
