Abstract
Aim:Vascular leakage following cardiopulmonary bypass contributes to morbidity. Angiopoietin-1 and -2 are biomarkers of endothelial dysfunction. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes.Methods:Observational cohort study measuring Ang-1/-2 with a panel of cytokines in adults undergoing cardiopulmonary bypass.Results:Ang-2 levels increased immediately postop whereas Ang-1 levels decreased over time. No significant correlation was found with other inflammatory mediators. High correlation was found between the hospital length of stay and Ang-2 increase at 24 h (rho = 0.590; p < 0.0001). The predictors of Ang-2 increase were female gender, cross clamp time, transfusion of blood and absence of angiotensin-converting enzyme inhibitor as a pre-op medication.Conclusion:Angiopoietins can detect vascular leakage early and could impact patient's management to decrease length of stay after cardiac surgery.
Highlights
The phenomenon of vascular inflammation and leakage that occurs in the context of cardiac surgery, with cardiopulmonary bypass (CPB), provides a unique experimental model in humans
We confirmed that the association of angiopoietin changes and CBP/cross-clamp time
A significant correlation was found between hospital length of stay and Ang-2 increase at 24 h
Summary
Vascular leakage following cardiopulmonary bypass contributes to morbidity. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes. Our aim was to characterize Ang-1 and Ang-2 changes and their association with preoperative and operative clinical characteristics, as well as with a panel of inflammatory markers
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