Abstract
Treatment for hypertensive crises with sodium nitroprusside was reported1-4 many years ago and it was shown to be rapidly effective in controlling various hypertensive states including the hypertension induced by pheochromocytoma after phentolamine was no longer effective.5 Its systemic hemodynamic effects were studied in man and its hypotensive action was con6rmed.6 However, it was not used widely at least partly because of its toxicity. 7-g There has been wide recent clinical interestlO-l3 in the use of the drug, however, and its hemodynamic effects have been restudied in subjects with coronary artery disease or cardiomyopathy14 and its renal effects were studied in hypertensive subjects15 and in the dog.16The data obtained previously in dogs’ and rnan6,14,15 did not include observations concerning coronary blood flow and myocardial metabolism. This seems of critical importance in hypotensive subjects. Therefore the present study was done.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call