Abstract
Keloids and hypertrophic scars pose significant challenges in clinical management due to their propensity for recurrence and their impact on patient’s quality of life. This systematic review evaluates the efficacy of various treatment modalities for these scars, with an emphasis on clinical outcomes, symptom alleviation, and recurrence rates. A comprehensive literature search identified studies published between 2014 and 2024, encompassing randomized controlled trials and observational studies. Results indicate that advanced therapies, such as botulinum toxin type A (BTX-A) and platelet-rich plasma (PRP), exhibit superior outcomes compared to traditional treatments, including triamcinolone acetonide (TAC), particularly concerning scar appearance and safety profiles. Furthermore, combination therapies, such as intralesional cryotherapy and CO2 fractional laser with intense pulsed light (IPL), demonstrated promising results in enhancing scar reduction and patient satisfaction. This review underscores the necessity of personalized treatment strategies tailored to individual patient requirements, taking into account factors such as scar characteristics and skin types. Future research should concentrate on optimizing treatment regimens to maximize efficacy while minimizing adverse effects, thereby ensuring long-term success in the management of keloids and hypertrophic scars.
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