Systematic Biology Basis of Constitution and Essence of Traditional Chinese Medicine Syndromes in Spleen Qi Deficiency of Chronic Atrophic Gastritis

Abstract

Chronic Atrophic Gastritis (CAG) is a common digestive disease without specific treatment. Traditional Chinese Medicine could achieve significant effects for treatment of CAG. CAG could be divided into different syndromes according to the syndrome differentiation, which has not been widely accepted in western medicine. Our aim is to provide evidence for the existence of syndrome differentiation through comprehensive analysis, combining immunomics techniques with electronic gastroscopy, pathological examination and symptom scores evaluation. According to comparing the changes pre- and after treatment both in spleen qi deficiency and damp-heat syndrome groups, our research try to verify that treatment of TCM works only when the therapies match the corresponding syndromes; or there could be little or no effects through treatment. Clinical Trial Registry: It was registered in the Chinese Clinical Trial Registry (ChiCTR-TRC-14004088). Funding: The trial is financially supported by Natural Science Foundation of China. Declaration of Interests: The authors declare that no conflict of interest exists. Ethical Approval Statement: The study was conducted in compliance with the Declaration of Helsinki and the requirements of clinical trials by the Drug Administration Law of the People's Republic of China. The protocol and informed consent were reviewed and approved by the Beijing University of Chinese Medicine Clinical Trials and Biomedical Ethics Committee (No. 2013-06-20).