Abstract
Objective: The aim of this study was to analyze the indicated lipid-lowering therapy and verify the achievement of the recommendedlipid goals during hospitalization and early follow-up, after the systematic application of a lipid managementalgorithm based on current recommendations.Methods: Patients hospitalized for acute coronary syndrome or programmed revascularization surgery were prospectivelyincluded in the study. A lipid management algorithm, including; 1) early indication of high-intensity statins during hospitalizationand 2) early follow-up (6 and 12-week controls), was systematically applied. The therapy indicated was based on positiondocuments of the Argentine Society of Cardiology. Achievement of LDL-C goals (<70 mg/dl) at 6 and 12 weeks was analyzed.Results: A total of 292 patients were prescribed statins (high-intensity in 95.9% of cases) at hospital discharge. AT 6 weeks,62.5% reached the LDL-C goal. The therapeutic plan was modified in 36.3% of patients (increased dose of statins in 19.7%and addition of ezetimibe in 67.7%). At 12 weeks, 69.1% of the subgroup which has not fulfilled the goal at 6 weeks, attainedthe lipid target. A PCSK9 inhibitor (PCSK9i) was indicated in 7 patients. Overall, 88.4% of patients achieved the LDL-C goalat 12 weeks.Conclusion: Many cardiovascular high-risk patients reached LDL-C goals at 12 weeks with the systematic application of aguideline-based algorithm. The indication of a PCSK9i was reserved for a reduced group of patients.
Published Version
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