Synthsis, characterization and antimicrobial studies of schiff base transition metal complexes of Cr(II), Mn(II), Co(II), Ni(II), Zn(II) and Cd(II) derived from cefadroxil

Abstract

In this study, the complexes of transition metals such as Cr (II), Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Cd (II) are synthesized from Schiff base(derived from cefadroxil). The techniques such as elemental analysis, TGA and DTA, UV-Spectral study, molar conductivity, atomic absorption spectroscopy and FTIR have been used for the characterization of Schiff base and the metal complexes. The compositions of the complexes are found to be ML2 ratio. The IR study shows that ligand is bi-dentate and coordinate bond to metal atom by N-azomethine and phenolic-O. The conductivity test of Schiff base and metal complexes show that both have the electrolytic nature. The thermal analysis data shows that water molecules have coordinate bonds with transition metal atom or ion. The antibacterial study of both Schiff base and metal complexes are made and they were found to be better than the parent antibiotic.