Abstract
A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS,1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods.
Highlights
Antipyrine derivatives are reported to exhibit analgesic and anti –infammatory effects[1,2,3,4], antiviral[5], antibacterial[6] activities and have been used as hair colour additives[7] and to potentiate the local anesthetic effect of lidocaine[8]
Antipyrine Schiff base derivatives can serve as antiparasitic agents and their complexes with platinum(II) and cobalt(II) ions have been shown to act as antitumour substances[11] A search through the literature reveals that no work has been done on the transition metal complexes of Schiff base formed by the condensation of 4-aminoantipyrine with 5-bromo salicylaldehyde
Based on the two bands observed, octahedral geometry is proposed for the above complex[29]
Summary
Antipyrine derivatives are reported to exhibit analgesic and anti –infammatory effects[1,2,3,4], antiviral[5], antibacterial[6] activities and have been used as hair colour additives[7] and to potentiate the local anesthetic effect of lidocaine[8]. The ESR spectra of the Cu(II) complexes were recorded on Jeol, JES -A 200 ESR spectrometer at room temperature. In the ESI-mass spectrum of ligand (Figure 3), the molecular ion peak was observed at m/z 386 which is in good agreement with the molecular weight of the proposed structure.
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