Abstract
A synthetic study of the construction of the C1-C23 fragment of prorocentin-4, a novel linear polyketide, is described. The synthetic highlights include the acid catalyzed epoxide opening, Gilman reaction, Pd(OH)2 catalyzed transformation of a primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner-Wadsworth-Emmons (HWE) olefination reaction as key steps.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have