Synthetic, structural, and biochemical studies of organotin(IV) with Schiff bases having nitrogen and sulphur donor ligands.

Har Lal Singh,A K Varshney

doi:10.1155/bca/2006/23245

Abstract

Three bidentate Schiff bases having nitrogen and sulphur donor sequences were prepared by condensing S-benzyldithiocarbazate (NH2NHCS2CH2C6H5) with heterocyclic aldehydes. The reaction of diphenyltin dichloride with Schiff bases leads to the formation of a new series of organotin(IV) complexes. An attempt has been made to prove their structures on the basis of elemental analyses, conductance measurements, molecular weights determinations, UV, infrared, and multinuclear magnetic resonance (1H, 13C, and 119Sn) spectral studies. Organotin(IV) complexes were five- and six-coordinate. Schiff bases and their corresponding organotin complexes have also been screened for their antibacterial and antifungal activities and found to be quite active in this respect.

Highlights

The number and diversity of nitrogen and sulfur chelating agents used to prepare new coordination and organometallic compounds has increased rapidly during the past few years [1,2,3,4,5,6,7]
During the course of the present investigations, an attempt has been made to synthesize tin complexes by interacting Ph2SnCl2 and nitrogen, sulfur containing Schiff bases derived by condensation of heterocyclic aldehydes with S-benzyldithiocarbazate
Schiff bases were prepared by the stoichiometric reactions of S-benzyldithiocarbazate with heterocyclic aldehydes, which

Summary

INTRODUCTION

The number and diversity of nitrogen and sulfur chelating agents used to prepare new coordination and organometallic compounds has increased rapidly during the past few years [1,2,3,4,5,6,7]. The dithiocarbazate (NH2NHCS2−) and its substituted derivatives have been investigated [8,9,10,11,12,13,14,15,16,17] These compounds have received much attention and for further studies because (i) they provide an interesting series of ligands whose properties can be greatly modified by introducing different organic substituents, thereby causing a variation in the ultimate donor properties, (ii) the interaction of these donors with metal ions gives complexes of different geometries and properties, and (iii) these complexes are potentially biologically active. Excess solvent was removed from the filtrate and the compound was dried in vacuum and a colored sticky solid was obtained These were repeatedly washed with dry cyclohexene and petroleum ether and these complexes were purified by recrystallization from the same solvent (Table 1). Carbon, hydrogen, sulfur, nitrogen, and chlorine agree with the theoretical values within the limit of experimental error

Analytical methods

C N NH C

C-2 C-3 C-4 C-5 C-6 C-7 C-8 C-9 C-10 C-11 C-12 Aromatic carbons α

C6 H2 CS