Evaluation of Disease Resistance Potential of Diorganotin Complexes in Some Bacteria and Fungi

Abstract

The reaction of diphenyltin dichloride and dimethyltin dichloride with the ligands of Schiff base lead to the formation of a new series of bioactive organotin (IV) complexes. The isolated products are coloured solids soluble in most of the organic solvents. The bonding and coordination behaviour of these compounds are discussed by the support of electronic, infrared and multinuclear magnetic resonance (1H, 13C and 119Sn NMR) spectral studies. These investigations suggest that the ligands act in a bidentate manner, coordination through the sulphur and nitrogen atoms. Trigonal bipyramidal geometry is proved for 1:1 metal complexes and hexacoordinated geometry is assigned for 1:2 metal complexes. All the complexes are monomeric in nature as indicated by their molecular weight determinations. Conductivity measurements show them to be non-electrolyte as the conductance values in DMF lie in the range of 10-12 ohm-1 cm2 mol-1. Schiff bases and their corresponding organotin complexes have also been screened for their antifungal and antibacterial activities and found to be quite active in this respect. Testing of ligands and their organotin complexes for disease resistance have been successfully studied in vitro and in vivo experiments. Results were quite encouraging and these were compared with the standard pesticides Bavistin and Streptomycin.