Abstract
AbstractChemical binding or strong complexing of individual antigens (proteins, polysaccharides) or antigenic determinants with non‐natural membrane active polyelectrolytes results in formation of effective immunogens with high protective properties. These artificial antigenic conjugates develop strong immunogenicity also in the absence of T‐cells. The strength of the immune response is not controlled by Ir‐genes. An antigenic moiety of a conjugate is responsible for its “focusing” on B‐lymphocytes of the proper clone. Linear polyion moiety being adsorbed on the cell membrane surface aggregates membrane proteins and induces nonspecific transmembrane ionic permeability. K+‐flux from the cell and Ca+2‐flux into the cell disturb cell homeostasis and thus, pull trigger mechanism of K+, Na+‐ATPase and Ca+2‐ATPase activity. Then the cell synthesizing apparatus starts to operate. The covalent conjugates of Salmonella typhimurium and influenza A‐virus individual antigens with synthetic polyelectrolytes seem to represent a new generation of vaccinating macromolecules.
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