Abstract
A series of N-[5-dehydroabietyl-[1,3,4]thiadiazol-2-yl]-aromatic amide derivatives were synthesized from dehydroabietic acid. Their structures were characterized by IR, 1H NMR, MS, elemental analysis and single crystal X-ray diffraction. Four six-membered rings of 2b exhibited plane, half-chair and chair configurations, respectively. The antibacterial activity of these newly synthesized N-[5-dehydroabietyl-[1,3,4]thiadiazol-2-yl]-aromatic amides derivatives against Gram-negative bacteria and Gram-positive bacteria was also investigated using the minimum inhibition concentration method. Preliminary results indicated that five compounds displayed better antibacterial activity against Pseudomonas aeruginosa and Escherichia aerogenes compared to commercially available antibacterial agents of Bromogeramine and Ampicillin sodium.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
