Abstract
A novel Ca(II) coordination polymer, [CaL(4,4′-bipyridyl)(H2O)4]n (L = 1,6-naphthalenedisulfonate), was synthesized by reaction of calcium perchlorate with 1,6-naphthalenedisulfonic acid disodium salt and 4,4′-bipyridyl in CH3CH2OH/H2O. It was characterized by elemental analysis, IR, molar conductivity and thermogravimetric analysis. X-ray crystallography reveals that the Ca(II) coordination polymer belongs to the orthorhombic system, with space group P212121. The geometry of the Ca(II) ion is a distorted CaNO6 pengonal bipyramid, arising from its coordination by four water molecules, one nitrogen atom of 4,4′-bipyridyl molecule, and two oxygen atoms from two L ligands. The complex molecules form a helical chain by self-assembly. The antitumor activity of 1,6-naphthalenedisulfonic acid disodium salt and the Ca(II) coordination polymer against human hepatoma smmc-7721 cell line and human lung adenocarcinoma A549 cell line reveals that the Ca(II) coordination polymer inhibits cell growth of human lung adenocarcinoma A549 cell line with IC50 value of 27 μg/mL, and is more resistive to human lung adenocarcinoma A549 cell line as compared to 1,6-naphthalenedisulfonic acid disodium salt.
Highlights
The last few decades, many studies have focused on the metal-organic hybrid materials constructed by d-block or f-block cations and organic ligands, because they have potential applications in catalysis [1], photoluminescence [2], gas storage [3], molecule-based magnetic materials [4] and biomedical materials [5]
As part of our group to explore the synthesis and properties of alkaline earth metal complexes, we have been exploring the preparation of metal-organic hybrid materials by combining alkaline earth metal ions and organic ligands containing multi-oxygen and nitrogen atoms [7,8,9,10,11]
On the basis that metal-organic frameworks can be used as delivery vehicles for drug molecules [12], the antitumor activity of 1,6-naphthalenedisulfonic acid disodium salt and its Ca(II) coordination polymer against human hepatoma smmc-7721 cell line and human lung adenocarcinoma A549 cell line have been investigated
Summary
The last few decades, many studies have focused on the metal-organic hybrid materials constructed by d-block or f-block cations and organic ligands, because they have potential applications in catalysis [1], photoluminescence [2], gas storage [3], molecule-based magnetic materials [4] and biomedical materials [5]. In comparison to d-block cations, the coordination behavior and potential applications of alkaline earth metal complexes has remained largely an unexpored area [6]. As part of our group to explore the synthesis and properties of alkaline earth metal complexes, we have been exploring the preparation of metal-organic hybrid materials by combining alkaline earth metal ions and organic ligands containing multi-oxygen and nitrogen atoms [7,8,9,10,11]. On the basis that metal-organic frameworks can be used as delivery vehicles for drug molecules [12], the antitumor activity of 1,6-naphthalenedisulfonic acid disodium salt and its Ca(II) coordination polymer against human hepatoma smmc-7721 cell line and human lung adenocarcinoma A549 cell line have been investigated
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