Abstract
We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, 1H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand.
Highlights
IntroductionThe azo compounds with at least one azo (–N=N–) group, separated by two phenyl rings, have received tremendous attention both in fundamental and applied research [1,2,3,4,5,6]
Over the years, the azo compounds with at least one azo (–N=N–) group, separated by two phenyl rings, have received tremendous attention both in fundamental and applied research [1,2,3,4,5,6].the azo compounds are used extensively in textile industry, printing systems, biological staining and various photochemical productions [7,8,9]
The β-lactam antibiotic inhibits penicillin-binding proteins (PBPs), an enzyme required for the biosynthesis of bacterial cell wall, is suffering from resistance due to the release of β-lactamases enzyme, making the drug inactive [17,18]
Summary
The azo compounds with at least one azo (–N=N–) group, separated by two phenyl rings, have received tremendous attention both in fundamental and applied research [1,2,3,4,5,6]. Several new antibiotics failed to meet the challenges posed by multidrug-resistant pathogens [19,20,21]. We need such drugs which are sufficient to counteract and control the antibiotic resistance [19,20,21]. Various metal containing compounds have received significant attention in various biological applications, especially anticancer and antimalarial therapy. Investigations for metal-based antibacterial compounds are required as it anticipated that metal-based drugs may be helpful to overcome the development of antibiotic resistance [20]. The ligand and its complexes showed potential antimicrobial activity when screened against Gram +ve and Gram −ve pathogens
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