Synthesis, spectroscopic, thermal, structural investigations and biological activity studies of charge-transfer complexes of atorvastatin calcium with dihydroxy-p-benzoquinone, quinalizarin and picric acid

Abstract

The charge-transfer interactions between n-electron donor, atorvastatin calcium (ATC) and the electron acceptors, 2,5-dihydroxy-1,4-benzoquinone (DHBQ), 1,2,5,8-tetrahydroxy-9,10-anthraquinone (quinalizarin, Quiz), and 2,4,6-trinitrophenol (picric acid, PA) as π-acceptors have been studied spectrophotometrically in methanol by giving highly colored charge transfer complexes. The isolated solid charge-transfer complexes were characterized by elemental, IR, NMR, mass and thermal analysis to elucidate the chemical structure of the obtained solid CT complexes. The stoichiometry of the complexes was found to be 1:2 in [ATC]:[reagent] at DHBQ, quinalizarin, picric acid. This ratio gave the formed charge-transfer complexes in the formulas [(ATC)(DHBQ)2], [(ATC)(Quiz)2], and [(ATC)(PA)2] which was also confirmed by elemental and mass analysis. Their biological activities were also screened against various bacterial organisms. The obtained results are suitable for the estimation of antihyperlipidemic drug, ATC in pharmaceutical dosage forms.