Abstract
Mercury(II) complexes of thiolates having the general formula [Hg(RS)Cl2]−and [Hg(RS)2] have been prepared and characterized by IR and NMR (1H and13C) spectroscopy (RSH = 2-aminoethanethiol hydrochloride (Aet), cysteine (Cys), thiosalicylic acid (Ts) and 2-mercaptonicotinic acid (Mnt)). The spectral data suggests that the coordination of thiolates to mercury(II) occurs through the sulfur as indicated by the absence of S–H vibrations in IR and significant downfield shifts in the C–S resonance in13C NMR. However, in Mnt complexes, coordination through both sulfur and nitrogen is indicated. Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited a wide range of activities against gram-negative bacteria (E. coli, P. aeruginosa), while moderate activity was observed against a mold,P. citrinum.
Highlights
The interaction of mercury(II) with sulfur-containing molecules is an important area in bioinorganic chemistry because such studies provide models for naturally occurring sulfur-containing compounds [1,2,3,4,5,6,7,8,9,10]
As an attempt to explore further the chemistry of mercury–thiolates, the present study describes the synthesis of mercury complexes with thiolates and their characterization by IR and NMR (1H and 13C) spectroscopic methods
The reaction of HgCl2 with thiolates in a 1:1 or 1:2 molar ratio in methanol or methanol–water media resulted in a product of composition of the [Hg(RS)2] or [Hg(RS)Cl2]−
Summary
The interaction of mercury(II) with sulfur-containing molecules is an important area in bioinorganic chemistry because such studies provide models for naturally occurring sulfur-containing compounds [1,2,3,4,5,6,7,8,9,10]. Mercury(II) being a soft Lewis acid forms quit stable complexes with thiol groups [20,21,22,23], many thiolates remain labile and undergo ligand exchange, which is more pronounced in low (two and three)-coordinate compounds [24,25]. Mercury– thiolates provide representative examples of the structural diversity shown by the extensive family of metal thiolates [5,6,7,8,13,26,27,28] They are well known for their unusual coordination environment and exhibit structural variability both in the solution form and solid states. As an attempt to explore further the chemistry of mercury–thiolates, the present study describes the synthesis of mercury complexes with thiolates and their characterization by IR and NMR (1H and 13C) spectroscopic methods. The structures of ligands used in this study and their resonance assignments are described in Scheme 1
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