Abstract
Reactions of K2[PdCl4] with heterocyclic thiones in molar ratios of 1:2 and 1:4 in water-methanol medium yielded the palladium(II) complexes with the general formula of either [Pd(L)Cl2], [Pd(L)2]Cl2or [Pd(L)4]Cl2where L ═ Imidazolidine-2-thione (Imt), 2-Mercaptopyridine (Mpy), 2-Mercaptopyrimidine (Mpm), 6-Mercaptopurine (6-Mp) and Thionicotinamide (Tna). The complexes were characterized by elemental analysis and spectroscopic (IR,1H and13C NMR) methods. An upfield shift in the >C═S resonance of thiones in13C NMR and downfield shift in N–H or aromatic proton resonances in1H NMR are consistent with the sulfur coordination to palladium(II). The complexes were screened for antibacterial activity, and the results showed that the complexes exhibited moderate activities as compared to that of a standard drug.
Highlights
Heterocyclic thiones are among the ligand systems used to mimic bio-relevant metal–sulfur interactions and the complexes of heterocyclic thiones such as imidazolidine-2-thione (Imt), diazinane-2-thione (Diaz) and their derivatives with transition metals are of significant interest from bioinorganic chemistry point of view [1,2,3,4,5,6,7,8,9,10]. 6-Mercaptopurine and its riboside are anticancer metabolites and their complexes of Pd(II) and Pt(II) are known to exhibit antitumor activity [11,12,13]
The antibacterial activity of all synthesized metal complexes has been investigated against four bacteria, two G(+) i.e. Staphylococcus aureus ATCC 25923, Bacillus subtilis DSM 3256 (Germany), and two G(−) bacterial strains i.e. Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 10197 by the agar well diffusion method [51,52,53]
The palladium(II) complexes of the types, [Pd(thione)2Cl2] and [Pd(thione)4]Cl2 were obtained from reaction of K2[PdCl2] with thiones in 1:1 and 1:2 molar in methanol–water media
Summary
Heterocyclic thiones are among the ligand systems used to mimic bio-relevant metal–sulfur interactions and the complexes of heterocyclic thiones such as imidazolidine-2-thione (Imt), diazinane-2-thione (Diaz) and their derivatives with transition metals are of significant interest from bioinorganic chemistry point of view [1,2,3,4,5,6,7,8,9,10]. 6-Mercaptopurine and its riboside are anticancer metabolites and their complexes of Pd(II) and Pt(II) are known to exhibit antitumor activity [11,12,13]. 6-Mercaptopurine and its riboside are anticancer metabolites and their complexes of Pd(II) and Pt(II) are known to exhibit antitumor activity [11,12,13] In view of this importance, several complexes of thiones with Cu(I) [14,15,16,17], Ag(I) [18,19,20,21,22,23,24], Au(I) [25,26,27], Mo(II) [28], Pd(II) [29,30,31,32,33,34], Zn(II) [35,36,37,38,39], Cd(II) [39,40,41,42,43,44,45] and Hg(II) [46,47,48,49,50] have been widely studied. Tirmizi et al / Synthesis, spectral and antibacterial studies of Pd(II) complexes of heterocyclic thiones 301
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