Synthesis, Spectral and Electrochemical Studies of Co(II) and Zn(II) Complexes of a Novel Schiff base Derived from Pyridoxal

Abstract

A novel Schiff-base, N − (4- n -butyl)phenylpyridoxaldimine (Hbppyr), was prepared and structurally characterized on the basis of elemental analyses, and mass, NMR & IR spectral data. Hbppyr was found to coordinate through the azomethine nitrogen and phenolate oxygen in [M(bppyr) 2 (H 2 O) 2 ].nH 2 O where M = Co and Zn; non-coordination through pyridine nitrogen was implied by the IR spectral data as well as by the cyclic voltammograms of Hbppyr in its free and complexed forms. Pyridoxal-derived ligands have been continuously attracting the attention of number of scientists, mainly for the evolution of iron chelators for the treatment of iron overload disease and cancer. [1–6] Recently, some important review articles appeared on specifically pyridoxal isonicotinoyl hydrazone (PIH) and its analogs in relation to its potential orally effective iron-chelating ability for the treatment of iron overload disease. [1,2] As a part of our systematic investigation[ 7 , 8 ] on 3 d and 4 f metal complexes of some novel Schiff base ligands, we report here the synthetic and spectral studies on Co(II) and Zn(II) complexes of pyridoxal-drived Schiff base, (4- n -butyl)phenylpyridoxaldimine (Hbppyr), 1.