Synthesis, Sensing Performance and DFT Studies of a Novel Coumarin-based Schiff Base As a Turn-on Fluorescence Probe for Zinc Ion Detection.

Abstract

The design and development of novel efficient fluorescent chemical sensors for the selective detection of ions is currently of significant importance in supramolecular chemistry. Since zinc is a ubiquitous, indispensable and the second most abundant metal ion in the human body, developing chemosensors that can accurately discriminate between Zn2+ and Cd2+ ions has been a challenge due to their similar properties as they are in the same group of the periodic table. Therefore, a technique to trace and visualize free zinc ions is demanded. In this study, an innovative coumarin-based Schiff base (L) was synthesized and characterized by 1H NMR, 13C NMR and mass spectroscopy. A novel "Turn On" fluorescence chemosensor platform was developed for trace amounts of Zn2+ ions. The fluorescence Job's plot measurement was used to determine the complexation ratio between the probe and Zn2+ ion, which showed a maximum point indicating the formation of a ML2 adduct. Additionally, the geometrical parameters calculated using DFT and TD-DFT calculations were in close agreement with the experimentally observed values.